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Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells
- Source :
-
Leukemia Research . Apr2005, Vol. 29 Issue 4, p401-405. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by NF-κB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC). [Copyright &y& Elsevier]
- Subjects :
- *TUMORS
*PROTEINS
*NF-kappa B
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 29
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 17427134
- Full Text :
- https://doi.org/10.1016/j.leukres.2004.09.010