Gender disparities related to clinical characteristics and outcomes of patients undergoing transseptal procedures.

Explore gender disparities in patients undergoing transseptal puncture (TSP) for selected transcatheter cardiac intervention procedures. Patients who underwent TSP from January 2015 through September 2021 were reviewed. Primary outcomes were procedural and in-hospital major adverse events. Secondary endpoints were procedural success and hospitalization length of stay (LOS) >1 day. Unadjusted and multivariable-adjusted logistic regression analyses were performed to assess gender differences for in-hospital adverse events. The study cohort comprised 510 patients (mean [SD] age, 74 [14.0] years); 246 women (48 %) underwent TSP for left atrial appendage occlusion (LAAO) or transcatheter edge-to-edge-repair (TEER). Compared with men, women were younger, had higher CHA 2 DS 2 -VASc scores, and were more likely to have had a prior ischemic stroke, but were less likely to have paroxysmal atrial fibrillation. After multivariable adjustment, there were no differences between genders in aborted or canceled procedures (odds ratio [OR]: 0.43; 95 % confidence interval [CI]: 0.10–1.96; p = 0.277), any adverse events (OR: 1.00; 95 % CI: 0.58–1.70; p = 0.98), major adverse events (OR: 1.60; 95 % CI: 0.90–2.80; p = 0.11), or death (OR: 1.00; 95 % CI: 0.20–5.00; p = 0.31). Subgroup analysis for LAAO procedures showed that at 30 days, women had higher rates of adverse events, major adverse cardiac events, and LOS >1 day. Men and women showed no differences in procedural success and in-hospital adverse outcomes in unadjusted analysis and after multivariable adjustment, despite women having a higher risk profile among patients undergoing TSP. However, compared with men, women undergoing LAAO experienced a higher rate of in-hospital adverse events irrespective of TSP. • We investigated gender disparities in cardiac procedures with transseptal puncture. • Women had a higher risk profile among patients undergoing TSP. • Men and women showed no differences in procedural success. • There was also no difference between sexes in in-hospital adverse outcomes. • Women undergoing LAAO had higher in-hospital adverse events irrespective of TSP. [ABSTRACT FROM AUTHOR]