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The association between the composition of the early-life intestinal microbiome and eczema in the first year of life.
- Source :
-
Frontiers in Microbiomes . 3/16/2023, p1-15. 15p. - Publication Year :
- 2023
-
Abstract
- Introduction: The early-life intestinal microbiome plays a crucial role in the development and regulation of the immune system. Perturbations in its composition during this critical period have been linked to the development of allergic diseases. Objective: This study aimed to investigate the association between the composition of the early-life intestinal microbiome and the presence of eczema in the first year of life using shotgun metagenomic sequencing and functional analyses (metabolic pathways). Methods: Stool samples from 393 healthy term infants collected at 1 week of age were analyzed with shotgun metagenomic sequencing. Environmental and clinical data were prospectively collected using 3-monthly validated questionnaires. Participants were clinically assessed during study visits at 12 months of age. Eczema was diagnosed by the UK diagnostic tool and by a research nurse. Data analysis was stratified by delivery mode. Results: Eczema was diagnosed in 16.4% (60/366) of participants by nurse diagnosis. Infants born by cesarean section (CS) with nurse-diagnosed eczema had a higher relative abundance of Escherichia, Shigella, Enterobacter, and Citrobacter and a lower relative abundance of Veillonella than CS-born infants without eczema. In addition, CS-born infants without eczema had a higher abundance of genes involved in lactic fermentation. Vaginally born infants with eczema had a higher relative abundance of Bacteroides and a lower abundance of Streptococcus. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 28134338
- Database :
- Academic Search Index
- Journal :
- Frontiers in Microbiomes
- Publication Type :
- Academic Journal
- Accession number :
- 174397658
- Full Text :
- https://doi.org/10.3389/frmbi.2023.1147082