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The Effect of Splenic Irradiation on Mean Fluorescence Intensity Values of HLA Antibody in Presensitized Patients Waiting for Kidney Transplantation.
- Source :
-
Transplantation Proceedings . Dec2023, Vol. 55 Issue 10, p2362-2371. 10p. - Publication Year :
- 2023
-
Abstract
- To explore the desensitization treatment of patients waiting for kidney transplantation, this article comparative analysis of the effect of splenic irradiation on mean fluorescence intensity (MFI) values of HLA antibodies of 4 presensitized patients. After splenic irradiation, the mean MFI values of HLA-I antibody in 4 patients all decreased (P ≤.001, P ≤.001, P ≤.001, P ≤.001), and 3 patients had a decrease in intensity level (P ≤.001, P =.001, P ≤.001); as for HLA-II antibody, the mean MFI values in 3 patients also decreased (P ≤.001, P =.025, P =.016), 1 patient had a decrease in intensity level (P ≤.001) and the other 2 cases had no significant changes (P = 1.000, P =.564). On the other hand, splenic irradiation reduces MFI values in different levels of HLA antibody. So, splenic irradiation can reduce the MFI values of HLA antibodies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KIDNEY transplantation
*FLUORESCENCE
*IRRADIATION
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00411345
- Volume :
- 55
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Transplantation Proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 174409612
- Full Text :
- https://doi.org/10.1016/j.transproceed.2023.09.018