Advances and prospects of natural dietary polyphenols as G-quadruplex stabilizers in biomedical applications.

G-quadruplexes (G4s) have arrested continuous interest in cancer research, and targeting G4s with small molecules has become an ideal approach for drug development. Plant-based dietary polyphenols have attracted much attention for their remarkable anti-cancer effects. Studies have suggested that polyphenols exhibit interesting scaffolds to bind G4s, which can effectively downregulate the proto-oncogenes by stabilizing those G4 structures. Therefore, this review not only summarizes studies on natural dietary polyphenols (including analogs) as G4 stabilizers, but also reveals their anti-cancer activities. Furthermore, the structural and antioxidant insights of polyphenols with G4s are discussed, and future development is proposed. These insights may pave the way for the development of the next generation of anti-cancer drugs targeting nucleic acids. [Display omitted] • Most of dietary polyphenols are effective G-quadruplex ligands. • Binding to G-quadruplex may be a mechanism to explain the anti-cancer of dietary polyphenols. • Dietary polyphenols offer the promising scaffolds to structure modification. [ABSTRACT FROM AUTHOR]