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Recent Trends in the Petasis Reaction: A Review of Novel Catalytic Synthetic Approaches with Applications of the Petasis Reaction.

Authors :
Saeed, Sadaf
Munawar, Saba
Ahmad, Sajjad
Mansha, Asim
Zahoor, Ameer Fawad
Irfan, Ali
Irfan, Ahmad
Kotwica-Mojzych, Katarzyna
Soroka, Malgorzata
Głowacka, Mariola
Mojzych, Mariusz
Source :
Molecules. Dec2023, Vol. 28 Issue 24, p8032. 19p.
Publication Year :
2023

Abstract

The Petasis reaction, also called the Petasis Borono–Mannich reaction, is a multicomponent reaction that couples a carbonyl derivative, an amine and boronic acids to yield substituted amines. The reaction proceeds efficiently in the presence or absence of a specific catalyst and solvent. By employing this reaction, a diverse range of chiral derivatives can easily be obtained, including α-amino acids. A broad substrate scope, high yields, distinct functional group tolerance and the availability of diverse catalytic systems constitute key features of this reaction. In this review article, attention has been drawn toward the recently reported methodologies for executing the Petasis reaction to produce structurally simple to complex aryl/allyl amino scaffolds. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
24
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
174460752
Full Text :
https://doi.org/10.3390/molecules28248032