An inducible mouse model of heart failure targeted to cardiac Drd5 deficiency detonating mitochondrial oxidative stress.

• Cardiac Drd5 leads to hypertrophic cardiomyopathy and heart failure through ROS, NADPH oxidase, and mitochondrial dysfunction. • Drd5 myh6 fl/fl -creERT2 mice mirror human heart failure, filling a gap in oxidative stress-induced HF models. • Targeting Drd5 -related pathways offers potential therapeutic avenues for heart failure treatment. [ABSTRACT FROM AUTHOR]