A general overview on bioprospecting sponge-associated bacteria in Indonesia.

Marine sponges are known as the producers of marine-derived bioactive compounds. Among all, sponges from Indonesia were reported as the second-highest contributors to many new sponge-derived compounds. A recent review on the bioactive potential of Indonesian sponges reported the potential of sponges from Indonesia to produce bioactive compounds, including alkaloids, terpenoids, peptides, macrolides, and polyketides. In addition to their ability to produce bioactive compounds, sponges harbor many different prokaryotic phyla, including Proteobacteria, Actinobacteria, and Cyanobacteria. Many reports have indicated the bioactive potential of Indonesian sponges. However, research on bioprospecting bacteria associated with Indonesian sponges remains limited and under-explored. The present study reviewed available reports on the diversity of bacteria associated with Indonesian sponges, including their bioactive potential. Available reports from 2011 to 2021 were collected, aiming to provide a general overview of bioprospecting sponge-associated bacteria in Indonesia. The bioactive potential of compounds derived from bacteria associated with Indonesian sponges was analyzed, for example for antimicrobial and anticancer. In addition to the review, the present study also discusses the opportunity and challenge of conducting marine bioprospecting, especially for bioprospecting sponge-associated bacteria. [ABSTRACT FROM AUTHOR]