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Tissue-resident memory T cells exhibit phenotypically and functionally heterogeneous in human physiological and pathological nasal mucosa.
- Source :
-
Clinical Immunology . Jan2024, Vol. 258, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Pathogens commonly enter mucosal barrier tissues and tissue-resident memory T cells (T RM) are essential for preventing mucosal lesions. However, the immunological properties of T RM cells in nasal mucosa are poorly known. In comparison with control tissues, decreasing CD103+ T RM cells were observed in Chronic rhinosinusitis with nasal polyps (CRSwNPs) and sinonasal inverted papilloma (SNIP), which presented high capability to produce effector cytokines. In CRSwNPs, we found that CD103+ T RM cells with higher cytokine and Granzyme B coexpressed high PD-1, CD103− T RM cells expressed higher IL-10. Homogenates isolated from CRSwNPs induced CD103 expression on peripheral T cells which could be inhibited by blocking TGF-β. The frequencies of CD103+ T RM cells in CRSwNPs were extremely negatively correlated with neutrophil infiltration. CD103+ T RM cells from Staphylococcus aureus positive CRSwNPs had a stronger response to SEB. Taken together, two phenotypically and functionally distinct subsets of T RM cells exist in nasal tissues and play critical roles in the progress of CRSwNPs and SNIPs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NASAL mucosa
*IMMUNOLOGIC memory
*T cells
*MUCOUS membranes
*NASAL polyps
Subjects
Details
- Language :
- English
- ISSN :
- 15216616
- Volume :
- 258
- Database :
- Academic Search Index
- Journal :
- Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 174501932
- Full Text :
- https://doi.org/10.1016/j.clim.2023.109860