A New Ergosterol-Type Steroid Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus sp. TE-65L.

Chemical investigation on the fungal strain Aspergillus sp. TE-65L, which was previously isolated from cultivated tobacco (Nicotiana tabacum L.), led to the production of four steroids including a new ergosterol-type steroid, namely aspergosterol A (1). Their chemical structures were established by detailed spectroscopic analysis of 1D/2D NMR and HRESIMS data. Compound 1 was found to possess antiphytopathogenic activities against Alternaria alternate, Botrytis cinerea, and Fusarium oxysporum, with MIC values of 4, 8, and 16 μg/mL. [ABSTRACT FROM AUTHOR]