Back to Search
Start Over
Dietary flaxseed oil induces production of adiponectin in visceral fat and prevents obesity in mice.
- Source :
-
Nutrition Research . Jan2024, Vol. 121, p16-27. 12p. - Publication Year :
- 2024
-
Abstract
- Induction of obesity by dietary fats and oils differs according to the type of fat. Adiponectin is believed to be related to obesity prevention. We hypothesized that flaxseed oil is important for preventing obesity and producing adiponectin. To clarify this hypothesis, we investigated the relationship between obesity and different fat sources in mice fed diets with 6 types of fat and oils. C57BL/6J mice were given a control diet containing 5% corn oil or a high-fat diet containing 20% of either lard, palm oil, rapeseed oil, oleate-rich safflower oil, corn oil, or flaxseed oil for 14 weeks. In another experiment, mice were given a control diet and rosiglitazone (10 mg/kg body weight) by oral gavage for 1 week. At the end of study, plasma adiponectin and expression of fatty acid metabolism–related factors in white and brown adipose tissue and the liver were measured. Dietary flaxseed oil, which is rich in α-linolenic acid, did not induce obesity. Flaxseed oil resulted in increased β-oxidation–related factors in epididymal white adipose tissue, decreased fatty acid synthesis–related factors in the liver, and thermogenesis-related factor in brown adipose tissue following increase of plasma adiponectin. The results suggested that increase in plasma adiponectin after intake of flaxseed oil may be due to altered expression of AdipoQ and peroxisome proliferator-activated receptor γ in epididymal white adipose tissue. Flaxseed oil increased expression of adiponectin in visceral fat and regulated obesity-controlling fatty acid metabolism-related factors in white adipose tissue and liver, and thermogenesis-related factor in brown adipose tissue. A high-fat diet containing lard or palm oil induced obesity, whereas a high-fat diet containing flaxseed oil prevented it. Flaxseed oil promoted mRNA expression of AdipoQ in eWAT, but not in sWAT. Plasma adiponectin induced by flaxseed oil related to regulation of β-oxidation–related factors in eWAT, fatty acid synthesis–related factors in the liver, and thermogenesis-related factor in BAT. Abbreviations: BAT, brown adipose tissue; eWAT, epididymal white adipose tissue; sWAT, subcutaneous white adipose tissue. [Display omitted] [ABSTRACT FROM AUTHOR]
- Subjects :
- *PREVENTION of obesity
*LINSEED oil
*ANIMAL experimentation
*LIVER
*PALM oil
*ROSIGLITAZONE
*LINOLENIC acids
*PEROXISOME proliferator-activated receptors
*GENE expression
*ADIPONECTIN
*DESCRIPTIVE statistics
*CORN oil
*MESSENGER RNA
*CANOLA oil
*EPIDIDYMIS
*BODY temperature regulation
*ADIPOSE tissues
*ANTIOBESITY agents
*MICE
*DIETARY fats
*SAFFLOWER oil
*FATTY acids
*OXIDATION-reduction reaction
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 02715317
- Volume :
- 121
- Database :
- Academic Search Index
- Journal :
- Nutrition Research
- Publication Type :
- Academic Journal
- Accession number :
- 174579833
- Full Text :
- https://doi.org/10.1016/j.nutres.2023.11.004