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Diagnostic value and role of serum miR-15a-5p in patients with schizophrenia.

Authors :
Xu, Zhen
Yang, Ruidong
Chen, Guanwen
Jiang, Mingjun
Source :
Annals of General Psychiatry. 1/5/2024, Vol. 23 Issue 1, p1-10. 10p.
Publication Year :
2024

Abstract

Background: More and more studies have confirmed that the heredity plays an important role in mental disorders, especially microRNA. The objective of this research was to explore the level of miR-15a-5p in patients with schizophrenia (SZ), and to evaluate the feasibility of this miRNA as a diagnostic marker of SZ. Methods: The serum level of miR-15a-5p in patients with SZ and healthy people was detected by RT-qPCR. ROC curve was established to evaluate the clinical diagnostic significance of miR-15a-5p in SZ. Pearson correlation coefficient was used to evaluate the correlation between miR-15a-5p level and PANSS score. Logistic regression was used to assess the risk factors of SZ. A rat model of SZ was established, and the effects of miR-15a-5p on the behavior of SZ rats were observed through water maze test and open field test. Results: The serum level of miR-15a-5p in patients with SZ was significantly increased, and ROC analysis revealed that miR-15a-5p had clinical diagnostic value in SZ. High level of miR-15a-5p was positively correlated with the positive symptom, negative symptom and general psychopathology subscore of patients. Logistic regression results showed that miR-15a-5p was a risk factor affecting the occurrence of SZ. Animal studies showed that the serum level of miR-15a-5p was elevated in the SZ rats, and inhibiting the expression of miR-15a-5p has a positive effect on improving the cognitive function and anxiety behavior of SZ rats. Conclusions: Serum miR-15a-5p is a risk factor for SZ, which is of great significance for the diagnosis of SZ. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1744859X
Volume :
23
Issue :
1
Database :
Academic Search Index
Journal :
Annals of General Psychiatry
Publication Type :
Academic Journal
Accession number :
174638588
Full Text :
https://doi.org/10.1186/s12991-023-00489-4