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Protective Effects of Resveratrol Carbon Dots Against 6-OHDA-Induced Neurotoxicity in SH-SY5Y Cells.
- Source :
-
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi . 2023, Vol. 20 Issue 3, p508-512. 5p. - Publication Year :
- 2023
-
Abstract
- Background: We aimed to investigate the ability of resveratrol carbon dots (RES C-Dots) to protect SHSY5Y cells from oxido-inflammatory stress and apoptosis caused by 6-hydroxydopamine (6-OHDA). Materials and Methods: In vitro PD model was generated in SH-SY5Y cells by administering of 200 µM 6- OHDA for 24 hours. Different concentrations of RES C-Dots (12.5, 25, and 50 µg/mL) were applied to the cells 30 minutes before administration of 6-OHDA. Results: We observed that application of RES C-Dots prevented cell death induced by 6-OHDA and maintained cell viability. As expected, RES C-Dots prevented oxidative damage induced by 6-OHDA - by strengthening the total amount of antioxidants and lowering the total amount of oxidants in SH-SY5Y cells. Similarly, RES C-Dots markedly alleviated the secretion of inflammatory factors (TNF-α and IL-1β) promoted by 6-OHDA. Furthermore, RES C-Dots prevented apoptosis induced by 6-OHDA by suppressing caspase-3 mRNA expression level. Conclusions: RES C-Dots rescued SH-SY5Y cells from 6-OHDA- induced damage by modulating the oxidoinflammatory and apoptotic response. This report indicates enounces that RES- synthesised C-Dots may have promising curative potential for PD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG therapy for Parkinson's disease
*NEUROTOXICOLOGY
*CYTOKINES
*IN vitro studies
*SYNDROMES
*NEURONS
*CARBON
*ANTIOXIDANTS
*APOPTOSIS
*OXIDIZING agents
*INTERLEUKIN-1
*RESVERATROL
*OXIDATIVE stress
*DOPAMINE
*GENE expression
*PARKINSON'S disease
*TUMOR necrosis factors
*MESSENGER RNA
*DESCRIPTIVE statistics
*CELL lines
*NANOPARTICLES
*CASPASES
Subjects
Details
- Language :
- English
- ISSN :
- 13049623
- Volume :
- 20
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 174682176
- Full Text :
- https://doi.org/10.35440/hutfd.1318802