Mitochondrial entry gate as regulatory hub.

Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network. • Multifunctional properties of translocase of outer mitochondrial membrane (TOM) • TOM complex interacts with preproteins, cytosolic chaperones and translocases. • TOM participates in quality control pathways and stress response reactions. • TOM as regulatory hub in protein biogenesis, cellular proteostasis and signaling [ABSTRACT FROM AUTHOR]