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Double-Blind Multicenter Randomized Clinical Trial Comparing Glucagon vs Placebo in the Resolution of Alimentary Esophageal Impaction.

Authors :
de Benito Sanz, Marina
Tejedor-Tejada, Javier
Mangas-Sanjuan, Carolina
de la Santa, Eva
Cebrian, Irene
Talegón, Raquel
Sánchez-Ocaña, Ramón
Pérez-Pariente, José M.
Pérez-Miranda, Manuel
García-Alonso, Francisco Javier
Source :
American Journal of Gastroenterology (Lippincott Williams & Wilkins). Jan2024, Vol. 119 Issue 1, p87-96. 10p.
Publication Year :
2024

Abstract

INTRODUCTION: The aim of this study was to compare the effectiveness of glucagon vs placebo in resolving esophageal foreign body impaction (EFBI), as well as the length of the procedure and adverse events. METHODS: This was a multicenter, randomized, double-blind trial involving consecutive patients diagnosed with alimentary EFBI. Participants were randomized to receive either 1 mg of intravenous glucagon or placebo. All patients underwent upper endoscopy, and adverse events were assessed through a protocolized telephonic interview 7 days later. RESULTS: The study included 72 subjects in the glucagon group and 68 in the placebo group. The foreign body was not identified in 23.6% of subjects in the glucagon group and 20.6% of subjects in the placebo group (difference 3%, 95% confidence interval -10.7% to 16.8%, P = 0.67). The median time required to remove the foreign body was similar in both groups 4 minutes (range 2-10) in the glucagon group and 3.5 minutes (range 2-7) in the placebo group (difference 0.5 minutes, 95% confidence interval -1.3 to 2.3; P = 0.59). The most common adverse event reported in both groups was mild pharyngeal pain. DISCUSSION: Glucagon is no more effective than placebo in resolving EFBI or shortening the time required to remove the foreign body (EUDRA-CT number 2019-004920-40). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029270
Volume :
119
Issue :
1
Database :
Academic Search Index
Journal :
American Journal of Gastroenterology (Lippincott Williams & Wilkins)
Publication Type :
Academic Journal
Accession number :
174733178
Full Text :
https://doi.org/10.14309/ajg.0000000000002511