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Iridoids and other constituents from the leaves and stems of Valeriana officinalis var. latifolia.
- Source :
-
Phytochemistry . Feb2024, Vol. 218, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Fifty-nine compounds, including nineteen previously undescribed iridoids (valeriananols A−S) and an undescribed alkaloid (5′-isovaleryl uridine), were isolated from the leaves and stems of Valeriana officinalis var. latifolia. Their structures were elucidated based on Mass spectrometry and NMR spectroscopy. The absolute configuration of valeriananols A−C, E−N, P, Q and S was determined by experimental and calculated electronic circular dichroism. Structurally, valeriananols A and B were two 1,3- seco -iridoids with a 3,6-epoxy moiety, valeriananols K and L were a pair of C-4 epimers, while valeriananol S was a 4′-deoxy iridoid glycoside. In addition, valeriananol P, stenopterin A and patriscabioin C exhibited significant inhibition on nitric oxide production with IC 50 values of 10.31, 3.93 and 8.69 μM, respectively. Furthermore, stenopterin A and patriscabioin C showed anti-proliferation activity on the MCF-7 cell line with IC 50 values of 17.28 and 13.89 μM, respectively. [Display omitted] • Twenty undescribed compounds were isolated from V. officinalis var. Latifolia. • Valeriananols A and B are two 1,3- seco -iridoids with 3,6-epoxy moiety. • Valeriananol S was a 4′-deoxy iridoid glycoside. • Three compounds showed significant inhibitory effects of nitric oxide production. • Stenopterin A and patriscabioin C showed cytotoxicity against the MCF-7 cell line. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRIDOIDS
*VALERIANA
*CYTOTOXINS
*NITRIC oxide
*MASS spectrometry
*CIRCULAR dichroism
Subjects
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 218
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 174760315
- Full Text :
- https://doi.org/10.1016/j.phytochem.2023.113934