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Self-reported childhood adversity, unhealthy lifestyle and risk of new-onset chronic kidney disease in later life: A prospective cohort study.
- Source :
-
Social Science & Medicine . Jan2024, Vol. 341, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- The prospective relation of childhood adversity with the risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the association of childhood adversity with new-onset CKD and examine the potential modifications by unhealthy lifestyle on this association. A total of 115,453 adults without prior CKD at baseline were included from UK Biobank (2006–2010). Childhood adversity was retrospectively evaluated through online Childhood Trauma Screener in 2016. Six common lifestyle factors including smoking, body mass index, sleep, diet, physical activity and alcohol consumption, were combined into an unhealthy lifestyle score. New-onset CKD was the primary outcome. The average age of participants in the study was 55.3 (SD, 7.7) years, and 39.3% of them were male. During a median follow-up duration of 14.1 years, 1905 participants developed new-onset CKD. Childhood adversity was significantly positively related with the risk of new-onset CKD in dose-response pattern. Each additional type of childhood adversity was associated with a 12% increment in the risk of developing CKD (adjusted hazard ratio (HR)1.12; 95% CI 1.08, 1.16). Among participants with high unhealthy lifestyle score, those with 4–5 types of childhood adversity increased the 1.73-fold risk of incident CKD (95% CI 1.17, 2.54) compared with those free of any childhood adversity. However, no statistically significant interaction was observed between unhealthy lifestyle and childhood adversity for new-onset CKD (P interaction = 0.734). Childhood adversity was significantly associated with an increased risk of new-onset CKD in a dose-response pattern regardless of unhealthy lifestyle. • Childhood adversity is highly prevalent and relates to poor health in late life. • Childhood adversity is a critical risk factor of new-onset CKD in adulthood. • Physical abuse was the strongest type associated with new-onset CKD. • Action of childhood adversity on incident CKD was independent of unhealthy lifestyle. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADVERSE childhood experiences
*LIFESTYLES
*CHRONIC kidney failure
*CONFIDENCE intervals
*SELF-evaluation
*INTERNET
*RETROSPECTIVE studies
*DIET
*RISK assessment
*SLEEP
*PHYSICAL activity
*HEALTH behavior
*AGE factors in disease
*ALCOHOL drinking
*DESCRIPTIVE statistics
*SMOKING
*BODY mass index
*LONGITUDINAL method
*DOSE-response relationship in biochemistry
*DISEASE risk factors
*ADULTS
*MIDDLE age
Subjects
Details
- Language :
- English
- ISSN :
- 02779536
- Volume :
- 341
- Database :
- Academic Search Index
- Journal :
- Social Science & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 174793311
- Full Text :
- https://doi.org/10.1016/j.socscimed.2023.116510