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Silver-catalyzed oxidative alkylation/alkynylation of 1,4-enynyl-3-ols with alkylbromides through radical 1,2-alkynyl migration.
- Source :
-
Catalysis Communications . Jan2024, Vol. 186, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- In this study, we have described a novel reaction between 1,4-enynyl-3-ols and alkyl bromides. The reaction was carried out in the presence of Ag 2 O, following a free radical 1,2-alkynyl migration pathway, which was confirmed through control experiments. This methodology offers several advantages, including high efficiency and a wide range of applicable substrates. A novel alkynylation/alkylation reaction between 1,4-enynyl-3-ols and alkyl bromides was herein described. The Ag 2 O-mediated transformation proceeded in a free radical 1,2-alkynyl migration pathway, which was verified by the control reactions. The methodology enjoyed priorities such as high efficiency and broad substrate scope. [Display omitted] • Alkynylation/alkylation reaction between 1,4-enynyl-3-ols and alkyl bromides. • A Ag 2 O-catalytic reaction. • A free radical 1,2-alkynyl migration reaction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RADICALS (Chemistry)
*ALKYL bromides
*FREE radicals
*ALKYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 15667367
- Volume :
- 186
- Database :
- Academic Search Index
- Journal :
- Catalysis Communications
- Publication Type :
- Academic Journal
- Accession number :
- 174794197
- Full Text :
- https://doi.org/10.1016/j.catcom.2023.106824