Preparation of biocompatible microsphere-cryogel composite system and controlled release of mupirocin.

In this study, polyvinylpyrrolidone/sodium carboxymethyl cellulose (PVP/NaCMC) microspheres containing an antibiotic agent Mupirocin (MP) were prepared. The effect of polymer/polymer ratio, cross-linking time and drug/polymer (d/p) ratio was investigated on MP release. The best condition for the release of MP was found to be 79.2%. Polyhydroxy methacrylate (pHEMA) based microsphere-cryogel composite system was prepared in a disk form using microspheres with the best drug release profile. Surface and bulk structures of cryogel disks were identified with scanning electron microscopy (SEM). The best MP release was found in 82.7% of the microsphere-cryogel composite system. [ABSTRACT FROM AUTHOR]