Emerging role of single-cell RNA sequencing in studies of cochlear aging.

This article discusses the emerging role of single-cell RNA sequencing (scRNA-seq) in studying cochlear aging, specifically age-related hearing loss (ARHL) or presbycusis. ARHL is a common disorder characterized by progressive hearing loss, particularly at high frequencies, and is associated with various comorbidities and economic costs. The cochlea, the auditory system's main component, is complex and consists of different cell types. Recent scRNA-seq studies have provided insights into cochlear development, noise-induced damage, and the effects of aging on specific cell types. A comprehensive scRNA-seq analysis of cochlear aging in mice has revealed cellular and molecular mechanisms associated with aging, providing a foundation for diagnostic and therapeutic strategies for ARHL. The article also highlights the importance of studying cochlear aging at the spatial level and using non-human primate models to gain a better understanding of cochlear aging in humans. [Extracted from the article]