基于决策树模型的注射用血栓通(冻干)联合常规 治疗用于不稳定型心绞痛的成本-效果分析.

OBJECTIVE: To assess the efficacy and cost-effectiveness of Xueshuantong injection ( lyophilized) (XIL) combined with conventional therapy in the treatment of unstable angina pectoris ( UAP ), so as to provide therapeutic and economic reference for the rational allocation of healthcare medical resources. METHODS: From the perspective of health system, a decision tree model for the treatment of UAP was constructed based on the evaluation results of one Meta-analysis, the intrinsic advantages and economic value of XIL were identified by cost-effectiveness analysis, with the intervention cycle for 14 days, and the sensitivity analysis was conducted on the results of this study. RESULTS: Meta-analysis showed that compared with the control group (conventional therapy), the efficacy of angina pectoris symptoms in the observation group (XIL+conventional therapy) was significantly better, and the results were more homogenous. The basic analysis results of pharmacoeconomic evaluation showed that the incremental costeffectiveness ratio of the two groups was 3 289. 11 yuan, indicated that compared with the control group, the observation group needed to spend 3 289. 11 yuan more for each additional case of effectively treated UAP patient. When the individual willingness-to-pay price was greater than 3 289. 11 yuan, the intervention regimen of observation group had more economical efficiency. The sensitivity analysis showed that the efficacy of angina pectoris symptoms and the conventional therapy cost of UAP in the control group had a certain effect on the study results. When the individual willingness-to-pay price was greater than 3 000 yuan, the intervention regimen of observation group had a higher economic probability, which is the same as the result of basic analysis. CONCLUSIONS: In terms of improving the angina pectoris symptoms in UAP patients, the choice of XIL combined with conventional therapy was more economical than conventional therapy alone when the individual willingness-to-pay price was greater than 3 000 yuan. [ABSTRACT FROM AUTHOR]