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Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites.

Authors :
Murao, Takuya
Kouzaki, Hideaki
Arai, Hiroyuki
Matsumoto, Koji
Nakamura, Keigo
Kawakita, Kento
Tojima, Ichiro
Shimizu, Shino
Yuta, Atsushi
Shimizu, Takeshi
Source :
International Forum of Allergy & Rhinology. Jan2024, Vol. 14 Issue 1, p57-67. 11p.
Publication Year :
2024

Abstract

Background: Allergic rhinitis (AR) impairs quality of life and affects nearly 40% of the Japanese population. Sublingual immunotherapy (SLIT) is the disease‐modifying treatment for AR, but requires the selection of a biomarker associate with clinical efficacy in patients with AR who are treated with SLIT. The present study sought to examine objective biomarkers used for assessing the clinical efficacy of SLIT. Methods: The authors examined the effects of 1 year of SLIT treatment with house dust mites (HDMs) using peripheral blood mononuclear cells (PBMCs) and serum from patients with AR. The prevalences of follicular regulatory T (Tfr), type 2 follicular helper T (Tfh2), type 2 helper T (Th2), conventional regulatory T (Treg), and type 1 regulatory T (Tr1) cells were examined by flow cytometry. Serum concentrations of HDM‐specific IgA, IgE, and IgG4 antibodies, and HDM‐induced production of interleukin (IL) 5 and IL‐10 from cultured PBMCs were evaluated by enzyme‐linked immunosorbent assay. Results: Following 1 year of SLIT, the prevalences of Tfr, conventional Treg, and Tr1 cells were significantly increased, whereas that of Th2 cells and Tfh2 cells were significantly decreased; the serum concentration of HDM‐specific IgG4 was significantly increased; and HDM‐induced production of IL‐5 from PBMCs was significantly decreased, while that of IL‐10 was significantly increased. The increase in the prevalence of Tfr cells after SLIT correlated positively with the improvement of clinical symptom scores. Conclusion: An increase in Tfr cells may play an important role in SLIT, and may be a useful indicator for the clinical efficacy of SLIT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20426976
Volume :
14
Issue :
1
Database :
Academic Search Index
Journal :
International Forum of Allergy & Rhinology
Publication Type :
Academic Journal
Accession number :
174818880
Full Text :
https://doi.org/10.1002/alr.23221