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Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy in China.

Authors :
Fan, Siyuan
Liu, Mange
Bai, Lin
Chen, Sixian
Hou, Bo
Lin, Nan
Yuan, Jing
Mao, Chenhui
Niu, Jingwen
Ren, Haitao
Zhao, Yanhuan
Zhang, Zaiqiang
Zhu, Yicheng
Peng, Bin
Guan, Hongzhi
Source :
Journal of NeuroVirology. Dec2023, Vol. 29 Issue 6, p692-698. 7p.
Publication Year :
2023

Abstract

The aim of this study is to analyze the clinical characteristics and outcomes of Chinese patients with progressive multifocal leukoencephalopathy (PML) who were treated with programmed cell death protein 1 (PD1) blockade therapies. We retrospectively analyzed patients who were admitted to our hospital between October 1, 2020, and October 1, 2022, diagnosed with PML and treated with PD1 blockade therapies. Four patients with PML who were treated with PD1 blockade therapies were identified. All patients were male, and their ages ranged from 19 to 54 years old. One patient (Case 2) exhibited mild pleocytosis, while three patients (Cases 2–4) had markedly reduced T lymphocyte cell counts prior to treatment. The time interval between symptom onset and treatment initiation ranged from six to 54 weeks. All patients received pembrolizumab treatment, with a total of two to four doses administered. Three patients who responded to pembrolizumab treatment showed clinical improvement starting around 8 weeks after the initiation of therapy. Although one patient did not show clinical improvement, they ultimately survived until the last follow-up. None of the patients in this study exhibited immune-related adverse events or immune reconstitution inflammatory syndrome. PD1 blockade appears to be a promising novel therapeutic option for PML; additional prospective studies are necessary to confirm its efficacy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13550284
Volume :
29
Issue :
6
Database :
Academic Search Index
Journal :
Journal of NeuroVirology
Publication Type :
Academic Journal
Accession number :
174840736
Full Text :
https://doi.org/10.1007/s13365-023-01180-w