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Recombination map tailored to Native Hawaiians may improve robustness of genomic scans for positive selection.
- Source :
-
Human Genetics . Jan2024, Vol. 143 Issue 1, p85-99. 15p. - Publication Year :
- 2024
-
Abstract
- Recombination events establish the patterns of haplotypic structure in a population and estimates of recombination rates are used in several downstream population and statistical genetic analyses. Using suboptimal maps from distantly related populations may reduce the efficacy of genomic analyses, particularly for underrepresented populations such as the Native Hawaiians. To overcome this challenge, we constructed recombination maps using genome-wide array data from two study samples of Native Hawaiians: one reflecting the current admixed state of Native Hawaiians (NH map) and one based on individuals of enriched Polynesian ancestries (PNS map) with the potential to be used for less admixed Polynesian populations such as the Samoans. We found the recombination landscape to be less correlated with those from other continental populations (e.g. Spearman's rho = 0.79 between PNS and CEU (Utah residents with Northern and Western European ancestry) compared to 0.92 between YRI (Yoruba in Ibadan, Nigeria) and CEU at 50 kb resolution), likely driven by the unique demographic history of the Native Hawaiians. PNS also shared the fewest recombination hotspots with other populations (e.g. 8% of hotspots shared between PNS and CEU compared to 27% of hotspots shared between YRI and CEU). We found that downstream analyses in the Native Hawaiian population, such as local ancestry inference, imputation, and IBD segment and relatedness detections, would achieve similar efficacy when using the NH map compared to an omnibus map. However, for genome scans of adaptive loci using integrated haplotype scores, we found several loci with apparent genome-wide significant signals (|Z-score|> 4) in Native Hawaiians that would not have been significant when analyzed using NH-specific maps. Population-specific recombination maps may therefore improve the robustness of haplotype-based statistics and help us better characterize the evolutionary history that may underlie Native Hawaiian-specific health conditions that persist today. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HAWAIIANS
*ROBUST statistics
*GENOMICS
*HAPLOTYPES
*POPULATION statistics
Subjects
Details
- Language :
- English
- ISSN :
- 03406717
- Volume :
- 143
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 174842364
- Full Text :
- https://doi.org/10.1007/s00439-023-02625-2