Expert commentary for fragile X premutation mimicking late onset hereditary spastic paraplegia.

• FXTAS is a clinically heterogenous disorder and should be considered as a possible diagnosis in cases of spastic ataxia. • Broader and more comprehensive genetic testing approaches may be required to ensure causative variants are not missed. • Long-read sequencing is a promising approach for the evaluation of spastic ataxias. [ABSTRACT FROM AUTHOR]