Back to Search
Start Over
Viscoelastic coagulation monitoring for tranexamic acid: personalised antifibrinolytic dosing?
- Source :
-
BJA: The British Journal of Anaesthesia . Feb2024, Vol. 132 Issue 2, p227-229. 3p. - Publication Year :
- 2024
-
Abstract
- E x vivo viscoelastic testing can be used to assess the concentration responses to tranexamic acid in blood samples obtained from pregnant women across the three trimesters and in non-pregnant controls. Minor variations in fibrinolysis across pregnancy suggest a target tranexamic acid blood concentration of 12.5 mg L−1 for complete inhibition of fibrinolysis. Although the data support the potential utility of viscoelastic testing using the ClotPro® TPA test in maintaining therapeutic tranexamic acid concentrations during postpartum haemorrhage, it might obscure potentially crucial endogenous fibrinolysis inhibitor interactions essential to the microcirculation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070912
- Volume :
- 132
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- BJA: The British Journal of Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 174844077
- Full Text :
- https://doi.org/10.1016/j.bja.2023.11.041