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Bifunctional Iminophosphorane Catalyzed Amide Enolization for Enantioselective Cyclohexadienone Desymmetrization.
- Source :
-
Angewandte Chemie International Edition . 1/25/2024, Vol. 63 Issue 5, p1-6. 6p. - Publication Year :
- 2024
-
Abstract
- The organocatalytic enolization of 2‐arylacetamides, followed by an enantioselective intramolecular conjugate addition to tethered 2,5‐cyclohexadienones, yielding 3D fused N‐heterocycles, is described. The transformation represents the first strong activating group‐free activation of carboxamides via α‐C−H deprotonation in a metal‐free, catalytic, and enantioselective reaction, and is achieved by employing a bifunctional iminophosphorane (BIMP) superbase. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENOLIZATION
*PROTON transfer reactions
*CARBOXAMIDES
*ORGANOCATALYSIS
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 63
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 174912162
- Full Text :
- https://doi.org/10.1002/anie.202315401