Effect of the drying type on the properties of granules and tablets produced by high shear wet granulation.

Although high shear mixers can represent a single-pot process, separate drying equipment is commonly employed. Limited literature exists on the use of a heating jacket coupled with a vacuum pump typically used in a single-pot setup, so this study compares the drying effects of a single-pot setup (DSP) and ventilated oven (DVO) on the properties of granules and tablets. Granules containing three actives of varying water solubility were produced and characterised. The results showed that DSP reduced the drying time and produced smaller, irregular, and weaker granules with different compression mechanisms. The tablets were produced and characterised. All tablets passed the uniformity test. Compression differences had no impact on tablet properties for poorly water-soluble actives, but altered properties for highly soluble actives due to increased active migration and crystallization on the granule surface. In conclusion, while DSP offers advantages, careful consideration of the drying technique is essential during product development. [Display omitted] • High shear wet granulation could be a single-pot process with numerous advantages. • The effect exerted by the use of a ventilated oven or the single-pot setup was investigated. • The single-pot setup reduces drying time and produces smaller, irregular, and brittle granules. • Highly soluble actives migrate to surface during drying, altering granule and tablet properties. • The choice of drying technique is crucial due to the impact on granule and tablet properties. [ABSTRACT FROM AUTHOR]