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Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiencyassociated type: a case report.
- Source :
-
Einstein (16794508) . 2023, Vol. 21, p1-4. 4p. - Publication Year :
- 2023
-
Abstract
- In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and/HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16794508
- Volume :
- 21
- Database :
- Academic Search Index
- Journal :
- Einstein (16794508)
- Publication Type :
- Academic Journal
- Accession number :
- 174924198
- Full Text :
- https://doi.org/10.31744/einstein_journal/2023RC0378