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Synergistic polymorphic interactions of phase II metabolizing genes and their association toward lung cancer susceptibility in North Indians.
- Source :
-
International Journal of Environmental Health Research . Jan2024, Vol. 34 Issue 1, p103-126. 24p. - Publication Year :
- 2024
-
Abstract
- Lung cancer is a multifactorial carcinoma with diverse heterogeneity. Genetic variations in drug-metabolizing enzymes may lead to defective detoxification and clearance of carcinogenic compounds. The high-order gene-gene interaction has been carried out between different genotypes of Phase II detoxification genes (NQO1, SULT1A1, NAT2, and EPHX1). Our results depict the genetic combination of SULT1A1 R213H with NAT2 × 5B L161L, SULT1A1 R213H with NAT2 × 5C K268R, EPHX1 H139R and NAT2 × 5B L161L exhibit a protective effect towards lung cancer risk. Further, the triple combinations of NQO1 P187S, EPHX1 Y113H, and EPHX1 H139R; NQO1 P187S, EPHX1 Y113H, and NAT2 × 6 R197Q; NQO1 P187S, EPHX1 Y113H, and NAT2 × 7 G286E; SULT1A1 R213H, EPHX1 H139R, and NAT2 × 7 G286E suggested a two-fold increased risk of lung cancer for subjects. Genetic polymorphisms of phase II detoxifying genes (NAT2, NQO1, EPHX1, SULT1A1) are prognostic markers for lung cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09603123
- Volume :
- 34
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Environmental Health Research
- Publication Type :
- Academic Journal
- Accession number :
- 174973565
- Full Text :
- https://doi.org/10.1080/09603123.2022.2133095