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Long-term Cardiovascular, Cerebrovascular, and Other Thrombotic Complications in COVID-19 Survivors: A Retrospective Cohort Study.
- Source :
-
Clinical Infectious Diseases . 1/15/2024, Vol. 78 Issue 1, p70-79. 10p. - Publication Year :
- 2024
-
Abstract
- Background Growing evidence suggests that some coronavirus disease 2019 (COVID-19) survivors experience a wide range of long-term postacute sequelae. We examined the postacute risk and burden of new-incident cardiovascular, cerebrovascular, and other thrombotic complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a highly vaccinated multiethnic Southeast Asian population, during Delta predominance. Methods This cohort study used national testing and healthcare claims databases in Singapore to build a cohort of individuals who had a positive SARS-CoV-2 test between 1 September and 30 November 2021 when Delta predominated community transmission. Concurrently, we constructed a test-negative control group by enrolling individuals between 13 April 2020 and 31 December 2022 with no evidence of SARS-CoV-2 infection. Participants in both groups were followed up for a median of 300 days. We estimated risks of new-incident cardiovascular, cerebrovascular, and other thrombotic complications using doubly robust competing-risks survival analysis. Risks were reported using 2 measures: hazard ratio (HR) and excess burden (EB) with 95% confidence intervals. Results We included 106 012 infected cases and 1 684 085 test-negative controls. Compared with the control group, individuals with COVID-19 exhibited increased risk (HR, 1.157 [1.069–1.252]) and excess burden (EB, 0.70 [.53–.88]) of new-incident cardiovascular and cerebrovascular complications. Risks decreased in a graded fashion for fully vaccinated (HR, 1.11 [1.02–1.22]) and boosted (HR, 1.10 [.92–1.32]) individuals. Conversely, risks and burdens of subsequent cardiovascular/cerebrovascular complications increased for hospitalized and severe COVID-19 cases (compared to nonhospitalized cases). Conclusions Increased risks and excess burdens of new-incident cardiovascular/cerebrovascular complications were reported among infected individuals; risks can be attenuated with vaccination and boosting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOSIS risk factors
*CEREBROVASCULAR disease risk factors
*CARDIOVASCULAR diseases risk factors
*COVID-19
*IMMUNIZATION
*CONFIDENCE intervals
*POST-acute COVID-19 syndrome
*COVID-19 vaccines
*RETROSPECTIVE studies
*ACQUISITION of data
*CASE-control method
*RISK assessment
*SOUTHEAST Asians
*RESEARCH funding
*MEDICAL records
*DESCRIPTIVE statistics
*SURVIVAL analysis (Biometry)
*SYMPTOM burden
*LONGITUDINAL method
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 78
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 175067962
- Full Text :
- https://doi.org/10.1093/cid/ciad469