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Liquid Biopsy: A New Avenue for the Diagnosis of Kidney Disease: Diabetic Kidney Disease, Renal Cancer, and IgA Nephropathy.

Authors :
Dybiec, Jill
Frąk, Weronika
Kućmierz, Joanna
Tokarek, Julita
Wojtasińska, Armanda
Młynarska, Ewelina
Rysz, Jacek
Franczyk, Beata
Source :
Genes. Jan2024, Vol. 15 Issue 1, p78. 12p.
Publication Year :
2024

Abstract

Kidney diseases are some of the most common healthcare problems. As the population of elderly individuals with concurrent health conditions continues to rise, there will be a heightened occurrence of these diseases. Due to the renal condition being one of the longevity predictors, early diagnosis of kidney dysfunction plays a crucial role. Currently, prevalent diagnostic tools include laboratory tests and kidney tissue biopsies. New technologies, particularly liquid biopsy and new detection biomarkers, hold promise for diagnosing kidney disorders. The aim of this review is to present modern diagnostic methods for kidney diseases. The paper focuses on the advances in diagnosing three common renal disorders: diabetic kidney disease, renal cancer, and immunoglobulin A nephropathy. We highlight the significance of liquid biopsy and epigenetic changes, such as DNA methylation, microRNA, piRNAs, and lncRNAs expression, or single-cell transcriptome sequencing in the assessment of kidney diseases. This review underscores the importance of early diagnosis for the effective management of kidney diseases and investigates liquid biopsy as a promising approach. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734425
Volume :
15
Issue :
1
Database :
Academic Search Index
Journal :
Genes
Publication Type :
Academic Journal
Accession number :
175078351
Full Text :
https://doi.org/10.3390/genes15010078