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Perioperative disabilities in activities of daily living are associated with worse prognosis after hepatectomy for colorectal liver metastasis.

Authors :
Mima, Kosuke
Hayashi, Hiromitsu
Maruno, Masataka
Yumoto, Shinsei
Matsumoto, Takashi
Tsukamoto, Masayo
Miyata, Tatsunori
Nakagawa, Shigeki
Nitta, Hidetoshi
Imai, Katsunori
Baba, Hideo
Source :
HPB. Feb2024, Vol. 26 Issue 2, p203-211. 9p.
Publication Year :
2024

Abstract

The number of vulnerable patients with colorectal liver metastasis (CRLM) has increased. This study aimed to clarify the relationship between perioperative activities of daily living (ADL) and clinical outcomes after hepatectomy for CRLM. Consecutive patients undergoing resection of CRLM from 2004 to 2020 were included. Pre- or postoperative ADL was evaluated according to Barthel index (BI) scores, which range from 0 to 100. Higher scores represent greater level of independence in ADL. Pre- or postoperative BI scores of ≤85 were defined as perioperative disabilities in ADL. Multivariable Cox proportional hazard regression models were utilised to estimate adjusted hazard ratios (HRs) and confidence interval (CI). A total of 218 patients were included, 16 (7.3%) revealed preoperative BI scores of ≤85, and 32 (15%) revealed postoperative BI scores of ≤85. In multivariate analyses, the perioperative disabilities in ADL were independently associated with shorter overall survival (HR, 1.96; 95% CI, 1.10–3.31; P = 0.023) and cancer-specific survival (HR, 2.31; 95% CI, 1.29–3.92; P = 0.006). Perioperative disabilities in ADL were associated with poor prognosis following hepatectomy for CRLM. Improving preoperative vulnerability and preventing functional decline after surgery may provide a favourable prognosis for patients with CRLM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1365182X
Volume :
26
Issue :
2
Database :
Academic Search Index
Journal :
HPB
Publication Type :
Academic Journal
Accession number :
175116295
Full Text :
https://doi.org/10.1016/j.hpb.2023.09.014