Testicular tissue re-implantation and the 'hostile testis'.

A recent study published in Human Reproduction investigated the feasibility of testicular tissue re-implantation as a method to restore fertility in infertile adult males. The study found that while the transplanted tissue was able to survive, it did not generate sperm, raising questions about the suitability of this approach for certain patients. The study also emphasized the importance of publishing negative results to inform future clinical applications. The authors discussed the ethical considerations of "first in human" procedures and the benefits of publishing negative results. They concluded that re-implantation of testicular tissue may be more beneficial for prepubertal boys facing gonadotoxic therapies, as their testicular tissue is healthier and more likely to generate functional sperm. [Extracted from the article]