Reaction of Tetrahydropyrimidine-2(1H)-thione Derivatives with Thiolated Acid Hydrazides as a Method of Synthesis of Biologically Active Ligands for Glyco-Gold Nanoparticles.

Authors :: Ershov, A. Y.
Lagoda, I. V.
Martynenkov, A. A.
Batyrenko, A. A.
Source :: Russian Journal of Organic Chemistry. Nov2023, Vol. 59 Issue 11, p2013-2014. 2p.
Publication Year :: 2023
Abstract: The reaction of 4-hydroxy-1-phenyl-6-methyltetrahydropyrimidine-2(1H)-thione with 6-sulfanylhexanoic and lipoic (thioctic) acid hydrazides forms 4-[ω-(sulfanylacyl)hydrazino]tetrahydropyrimidine-2(1H)-thiones in yields of 60–75%. The products are promising сo-ligands for the preparation of glyco-gold nanoparticles for biomedical purposes. [ABSTRACT FROM AUTHOR]

Subjects :: *HYDRAZIDES
*ACID derivatives
*LIGANDS (Chemistry)
*NANOPARTICLES

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