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Emerging role of NEDD8-mediated neddylation in age-related metabolic diseases.
- Source :
-
Ageing Research Reviews . Feb2024, Vol. 94, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Aging in humans is associated with abdominal distribution and remodeling of body fat and a parallel gradual increase in the prevalence of metabolic diseases such as obesity, type 2 diabetes mellitus and fatty liver disease, as well as the risk of developing metabolic complications. Current treatments might be improved by understanding the detailed mechanisms underlying the onset of age-related metabolic disorders. Neddylation, a post-translational modification that adds the ubiquitin-like protein NEDD8 to substrate proteins, has recently been linked to age-related metabolic diseases, opening new avenues of investigation and raising a potential target for treatment of these diseases. In this review, we will focus on the potential role of NEDD8-mediated neddylation in age-related metabolic dysregulation, insulin resistance, obesity, type 2 diabetes mellitus and fatty liver. We propose that alterations in NEDD8-mediated neddylation contribute to triggering insulin resistance and the development of age-related metabolic dysregulation, thus highlighting NEDD8 as a promising therapeutic target for preventing age-related metabolic diseases. • The elevation of NEDD8-mediated neddylation plays a critical role in the development of age-associated metabolic diseases. • NEDD8-mediated neddylation increases macrophage inflammation and adipogenesis and inhibits the browning of adipose tissue. • NEDD8-mediated neddylation increases hepatic gluconeogenesis, steatosis and fibrosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15681637
- Volume :
- 94
- Database :
- Academic Search Index
- Journal :
- Ageing Research Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 175300575
- Full Text :
- https://doi.org/10.1016/j.arr.2024.102191