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Unlocking CAR TÂ cell potential: Inosine-induced stemness and enhanced potency.
- Source :
-
Cancer Cell . Feb2024, Vol. 42 Issue 2, p175-177. 3p. - Publication Year :
- 2024
-
Abstract
- Adenosine (Ado) drives immune suppression in the tumor microenvironment. In this issue of Cancer Cell , Klysz et al. investigate Ado-mediated immunosuppression. Overexpression of Ado deaminase (ADA-OE), metabolizing Ado to inosine (INO), induces stemness and improves CAR T cell functionality. Likewise, exposure to INO enhances CAR T cells' function and induces stemness features. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 175300731
- Full Text :
- https://doi.org/10.1016/j.ccell.2024.01.003