Pancreatic β cell function versus insulin resistance: application of the hyperbolic law of glucose tolerance.

The article discusses the historical context and scientific understanding of diabetes, focusing on the interplay between pancreatic β cell function and insulin resistance, as elucidated by the hyperbolic law of glucose tolerance. Topics include the distinction between type 1 and type 2 diabetes, the debate over the primary pathogenetic defect in type 2 diabetes, and the application of the hyperbolic curve in studying glucose regulation and predicting disease onset.