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Euphzycopins A − D, macrocyclic diterpenoids with potential anti-inflammatory activity from Euphorbia Helioscopia.
- Source :
-
Fitoterapia . Mar2024, Vol. 173, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Four new diterpenoids (1–4) and four known diterpenoids (5–8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC 50 value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays. [Display omitted] • Four new diterpenoids (1–4) and four known diterpenoids (5 - 8) were purified from the whole plant of Euphorbia helioscopia L. • Compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system • Compound 4 showed strong activity with IC 50 values of 7.75 μM. Frther, the inhibitory effects of 4 on protein levels were determined using immunofluorescence assays. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 173
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 175343491
- Full Text :
- https://doi.org/10.1016/j.fitote.2024.105821