Development Pt/CoFe2O4/NC for efficient hydrogen evolution and sensitive detection of CEA.

In this study, we designed a Pt/CoFe 2 O 4 /NC composite material as an excellent electrocatalyst for hydrogen evolution reaction (HER) and used the HER signal to construct an electrochemical immunosensor for carcinoembryonic antigen (CEA) detection. Remarkably, Pt/CoFe 2 O 4 /NC demonstrated superior HER performance compared to alternative Pt-based materials. It exhibited a low overpotential of only 42 mV and a Tafel slope of 253 mV dec−1 in acidic medium. Furthermore, due to the excellent conductivity, large surface area, and superior HER performance of Pt/CoFe 2 O 4 /NC, it was used as secondary antibody (Ab 2) label to achieve signal amplification in the electrochemical immunosensor. The results showed that this immunosensor possessed high selectivity and sensitivity. The linear detection range is 1.0 × 10−4–5.0 ng mL−1, and the detection limit is 0.0134 pg mL−1. It has potential applications in the clinical analysis field. Due to the excellent conductivity, large surface area, and superior HER performance of Pt/CoFe 2 O 4 /NC, it was used as an Ab 2 label to achieve signal amplification in the electrochemical immunosensor. The results showed that this immunosensor possessed high selectivity and sensitivity. The linear detection range is 1.0 × 10−4–5.0 ng mL−1, and the detection limit is 0.0134 pg mL−1. It has potential applications in the clinical analysis field. [Display omitted] • Pt is loaded onto the CoFe 2 O 4 /NC by photoreduction method. • The Pt/CoFe 2 O 4 /NC with low Pt loading presents low overpotential and Tafel slope in the HER. • A novel electrochemical immunosensor based on Pt/CoFe 2 O 4 /NC was constructed for CEA detection. [ABSTRACT FROM AUTHOR]