Coumarins and flavones with anti-inflammatory activity isolated from the branches and leaves of <italic>Daphne retusa</italic>.

AbstractIn this study, two new (<bold>1, 13</bold>) and fourteen known (<bold>2</bold>–<bold>12, 14</bold>–<bold>16</bold>) compounds were isolated from the branches and leaves of <italic>Daphne retusa.</italic> On the basis of chemical evidence and spectral data analysis (UV, ECD NMR, and HR-ESI-MS), the structures of new compounds were elucidated. Furthermore, all compounds have been tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, and compound <bold>3</bold> showed obvious inhibitory effect. Through target screening and molecular docking technology, potential binding targets for compound <bold>3</bold> to exert anti-inflammatory effects have been predicted. [ABSTRACT FROM AUTHOR]