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Carrier rate of thalassemia among 25,910 high school students in Shaoguan area, China.
- Source :
-
Journal of Medical Screening . Mar2024, Vol. 31 Issue 1, p53-57. 5p. - Publication Year :
- 2024
-
Abstract
- Objectives: As one of the most common hereditary diseases, thalassemia affects a large number of people in China. The aim of this study was to investigate the feasibility of a method based on next-generation sequencing (NGS) for screening of thalassemia carriers among high school students in the Shaoguan area. Materials and Methods: The NGS-based method was performed using 25,910 high school students recruited from 38 schools. The screening yield was systematically analyzed. Before screening, a lecture on how the disease is inherited, the symptoms of thalassemia, and how to prevent it was given to 28,780 students. Results: Implying successful delivery of information on the disease, 90.03% (25,910 of 28,780) of the students agreed to join this program for thalassemia screening. A thalassemia carrier rate of 15.99% (4144 of 25,910) was found. Also, 69 rare genotypes (28 of α-thalassemia and 41 of β-thalassemia) and 9 novel variants were identified. Conclusions: This NGS-based method provided a feasible platform for high school population thalassemia screening. Combined with a clinical follow-up strategy, it could help eventually to prevent the births of affected children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09691413
- Volume :
- 31
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Medical Screening
- Publication Type :
- Academic Journal
- Accession number :
- 175542130
- Full Text :
- https://doi.org/10.1177/09691413231188069