Liquen plano penfigoide: una entidad clinicopatológica poco frecuente.

Lichen planus pemphigoid is a rare acquired autoimmune dermatosis with characteristics of lichen planus and bullous pemphigoid, which mainly affects young people. The most accepted theory about its origin is "epitope spreading," where the lichenoid inflammatory process damages the epidermal basement membrane, exposing autoantigens. Clinically, it presents classic lichenoid lesions and tense blisters on the lesional skin, as well as on the perilesional skin and healthy skin. In the histopathological study, a lichenoid reaction is found with the formation of a subepidermal blister and the presence of eosinophils. In the direct immunofluorescence there is a deposit of IgG and C3 in the basement membrane. Its treatment is aimed at controlling lichen planus to stop the antigenic stimulation that leads to the formation of autoantibodies against components of the basement membrane. For this, topical or systemic steroids are mainly used, depending on whether the lesions are localized or generalized, respectively. [ABSTRACT FROM AUTHOR]