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Palladium-catalyzed synthesis of indenoindoles via C-H activation and tandem synthesis of indenoisoquinolines via Suzuki-Miyaura coupling and annulation.
- Source :
-
ARKIVOC: Online Journal of Organic Chemistry . 2023, Vol. 2023, p1-20. 20p. - Publication Year :
- 2023
-
Abstract
- An efficient approach for synthesizing fused nitrogen containing heterocycles has been formulated. The approach relies on the use of 2-bromo-3-(arylamino)-1H-inden-1-one derivatives as precursors for the synthesis of indenoindoles and indenoisoquoinolines. The synthesis of indenoindoles is achieved via palladium-catalyzed C-H activation strategy, while a sequential palladium-catalyzed intermolecular Suzuki coupling followed by an intramolecular annulation process is used to synthesize indenoisoquinolines. The developed strategy offers indenone fused polycycles in moderate to good yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANNULATION
*SUZUKI reaction
*HETEROCYCLIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 15517004
- Volume :
- 2023
- Database :
- Academic Search Index
- Journal :
- ARKIVOC: Online Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 175597933
- Full Text :
- https://doi.org/10.24820/ark.5550190.p012.095