Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus.

Diabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research. Vitamin D's function in the development of type 1 and type 2 diabetes is supported by the discovery of 1,25 (OH)2D3 and 1-Alpha-Hydroylase expression in immune cells, pancreatic beta cells, and several other organs besides the bone system. A lower HBA1c level, metabolic syndrome, and diabetes mellitus all seems to be associated with vitamin D insufficiency. Most of the cross-sectional and prospective observational studies that were used to gather human evidence revealed an inverse relationship between vitamin D level and the prevalence or incidence of elevated HBA1c in type 2 diabetes. Several trials have reported on the impact of vitamin D supplementation for glycemia or incidence of type 2 diabetes, with varying degrees of success. The current paper examines the available data for a relationship between vitamin D supplementation and HBA1c level in diabetes and discusses the biological plausibility of such a relationship. [Display omitted] • Diabetes is a metabolic disorder that affects vital organ in the body and causes an increase in protein glycosylation. • Vitamin D deficiency appears to be linked to diabetes mellitus, metabolic syndrome, and a decreased HBA1c level. • The significance of vitamin D in the genesis of diabetes under RAGE stress is of paramount importance. • Vitamin D's function in the shielding of diabetes is supported by the discovery of 1,25(OH)2D3 in pancreatic beta cells. • Vitamin D supplementation may lower the HBA1c level, insulin resistance, or incidence of type 2 diabetes. [ABSTRACT FROM AUTHOR]