Innovations in Antibody-Drug Conjugate (ADC) in the Treatment of Lymphoma.

Simple Summary: Antibody–Drug Conjugate (ADC) is a novel therapy that has revolutionized the treatment of human cancers. In this review, we focus on the role of ADC in lymphoid malignancies. We summarize the latest advances of ADC development, and we discuss the landmark and most updated clinical trials. Chemoimmunotherapy and cellular therapy are the mainstay of the treatment of relapsed/refractory (R/R) lymphomas. Development of resistance and commonly encountered toxicities of these treatments limit their role in achieving desired response rates and durable remissions. The Antibody–Drug Conjugate (ADC) is a novel class of targeted therapy that has demonstrated significant efficacy in treating various cancers, including lymphomas. To date, three ADC agents have been approved for different lymphomas, marking a significant advancement in the field. In this article, we aim to review the concept of ADCs and their application in lymphoma treatment, provide an analysis of currently approved agents, and discuss the ongoing advancements of ADC development. [ABSTRACT FROM AUTHOR]