3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next?

The article discusses the recent advancements in protein structure prediction, with a focus on the achievements of AlphaFold. It explains how AlphaFold has made significant progress in accurately predicting 3D protein structures by dividing the problem into subproblems. However, the article acknowledges that there is still work to be done in mapping a single sequence to its real-world structure and dynamics. It compares AlphaFold 2 to previous methods and mentions other methods that have been developed in response. The article concludes by stating that the success of AlphaFold 2 has opened up new possibilities for structural biology research. [Extracted from the article]