Small extracellular vesicles (sEVs) mediate HBV infection and related mechanism research progress.

Small extracellular vesicles (sEVs) which are nanoscale membranous vesicles with lipid bilayers secreted by most cells, have received widespread attention from research scholars because they are important mediators of substance exchange and signaling. The basis of curing hepatitis B disease lies in fully understanding the molecular mechanism of HBV replication regulation. HBV mainly binds to membrane surface receptors for replication and transmission, but it is not the only route of infection. In addition to the receptor route, sEVs can transmit free viral HBV to uninfected hepatocytes. However, the mechanism of sEVs mediating HBV infection is not very clear to us, therefore, this paper will focuses on the relationship between sEVs secreted by hepatocytes after HBV infection and the transmission of HBV virus and the mechanism of infection, so as to provide a theoretical guidance for clinical treatment of hepatitis B virus infection. [ABSTRACT FROM AUTHOR]