Rebuilding the behavioral inhibition circuit to prevent opioid relapse.

Failure in behavioral suppression is a key feature in substance use disorders, potentially leading to compulsive drug seeking and relapse. In this issue of Neuron , Paniccia et al. 1 elucidated a heroin-damaged paraventricular nucleus of the thalamus (PVT)-accumbal circuit and how recovery of PVT function could prevent heroin relapse. Failure in behavioral suppression is a key feature in substance use disorders, potentially leading to compulsive drug seeking and relapse. In this issue of Neuron , Paniccia et al. elucidated a heroin-damaged paraventricular thalamo (PVT)-accumbal circuit and how recovery of PVT function could prevent heroin relapse. [ABSTRACT FROM AUTHOR]