Back to Search
Start Over
Systemic association of myelin oligodendrocyte glycoprotein antibody disease: A systematic review of literature.
- Source :
-
Neurology & Clinical Neuroscience . Mar2024, Vol. 12 Issue 2, p71-79. 9p. - Publication Year :
- 2024
-
Abstract
- Association of MOGAD with various autoimmune and paraneoplastic antibodies has been described in the literature. However, MOGAD with systemic manifestations is rarely encountered and requires a high index of suspicion for evaluation. Searching various databases, we identified 107 studies. After independently assessing the eligibility, finally, 29 studies were selected for review. A total of 1458 MOG patients were included in the study among whom systemic manifestations were present in 253 (17.3%) patients. SLE with ANA positivity was found in a total of 72 (28.4%) patients. Among them, anti‐dsDNA was positive in 10 (3.9%), anti‐smith in 3 (1.2%), anti‐SSA/SSB in 13 (5.1%), anti‐RNP in 3 (1.1%), anti‐Ro 52 in 1 (0.5%), and ENA in 1 (0.5%). APLA was positive in 10 (3.9%), ANCA in 10 (3.9%), RA in 31(12.9%) and thyroid antibody in 35 (13.8%) patients. Simultaneous CNS and PNS involvement was also seen in 21 (8.3%) patients. Systemic involvement is not an uncommon phenomenon in MOGAD and in future may add to the spectrum of the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20494173
- Volume :
- 12
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neurology & Clinical Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 175800258
- Full Text :
- https://doi.org/10.1111/ncn3.12790